Potential roles of microRNA-29a in the molecular pathophysiology of T-cell acute lymphoblastic leukemia.

摘要: Recent evidence has shown that deregulated expression of members the microRNA-29 (miR-29) family may play a critical role in human cancer, including hematological malignancies. However, roles miR-29 molecular pathophysiology T-cell acute lymphoblastic leukemia (T-ALL) not been investigated. Here, we show lower levels miR-29a were significantly associated with higher blast counts bone marrow and increased disease-free survival T-ALL patients. Furthermore, are extremely reduced cells compared to normal T cells. Microarray analysis following introduction synthetic mimics into Jurkat revealed downregulation several predicted targets (CDK6, PXDN, MCL1, PIK3R1, CXXC6), active passive DNA demethylation (such as DNMT3a, DNMT3b, TET TDG). Restoring Molt-4 led many genes commonly methylated T-ALL. Overall, our results suggest contribute altered epigenetic status T-ALL, highlighting its relevance physiopathology this disease.