Intestinal microcirculation and mucosal oxygenation during hemorrhagic shock and resuscitation at different inspired oxygen concentrations.

摘要: BACKGROUND Hypotensive resuscitation is the standard of care hemorrhagic shock resuscitation. The optimal level arterial pressure debated and there a lack data on relationships between pressure, microcirculation tissue oxygenation. We investigated relationship mean intestinal mucosal oxygen tension during at different inspired fraction concentration. METHODS study was divided into two phases: 32 mice were progressively exsanguinated then transfused in (MAP)-titrated steps 10 mm Hg. Mice randomized to four experimental groups: control group which sham underwent laparotomy three interventional groups with common phase exsanguination followed by progressive concentrations (FIO2) (15%, 30%, 100%). Intestinal oxygenation (intestinal PO2) microcirculatory parameters recorded each Hg MAP step. RESULTS During exsanguination, PO2 decreased linearly levels. Microcirculatory nonlinearly levels while they had linear PO2. hypoxia (PO2 ≤ 20 Hg) began 60 < associated high percentage animal (≥32%). Combination superior alone predicting Inversely, FIO2 = increased nonlinear Hypoxia (FIO2 15%) poorly tolerated. In hyperoxic 100%) became significantly higher than baseline values as soon 50 MAP. CONCLUSION shock, parameters. Associating allowed better prediction alone. A hypoxia. Normoxic 30%) sufficient restore