Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans

摘要: Animal models are indispensable to understand the lipid metabolism and metabolic diseases. Over last decade, nematode Caenorhabditis elegans has become a popular animal model for exploring regulation of metabolism, obesity, obese-related However, genomic functional conservation from C. humans remains unknown. In present study, we systematically analyzed genes involved in genome using comparative genomics. We built database containing 471 genome, then assigned most into 16 different pathways that were integrated network. 70% have human orthologs, with 237 being conserved humans, mice, rats, Drosophila, which 71 specifically related Moreover, RNA-mediated interference (RNAi) was used disrupt expression 356 available RNAi clones. found 21 strongly affect fat storage, development, reproduction, other visible phenotypes, 6 not previously been implicated phenotypes. This study provides first systematic insight elegans, supporting use as an increasingly prominent