Roles of Carbonic Anhydrase IX in Development of Pancreatic Cancer.
作者： Yuji Li , Ming Dong , Weiwei Sheng , Longping Huang
DOI: 10.1007/S12253-015-9935-6
关键词: Tumor size 、 Carbonic Anhydrase IX 、 Medicine 、 Pancreatic cancer cell 、 Metastasis 、 Gene silencing 、 Pathology 、 CA19-9 、 Cancer research 、 Normal tissue 、 Pancreatic cancer
摘要: The aim of this study was to the effects carbonic anhydrase IX (CA IX) towards invasion and metastasis pancreatic cancer. expressions CA in 58 cases cancer paired paracancerous normal tissues, obtained from 2005 2012 first Affiliated Hospital China Medical University, were detected, as well its different cell lines, aiming detect impacts silencing cells. higher than those tissues (P < 0.01), positively correlated with tumor size UICC staging 0.05), multivariate analysis showed that high expression independent risk factor prognosis 0.05). highly expressed AxPC–1 Miapaca–2, interference significant. could significantly inhibit AxPC-1 Miapaca. We support a pro-tumor role development progression
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sci-hub.se 参考文章(27)
Tuomo J. Karttunen, Jyrki Kivelã, Anna-Kaisa Parkkila, Silvia Pastorekova, Jaromir Pastorek, Abdul Waheed, William S. Sly, Seppo Parkkila, Hannu Rajaniemi, Antti J. Kivelã, Juha Saarnio, Differential expression of cytoplasmic carbonic anhydrases, CA I and II, and membrane-associated isozymes, CA IX and XII, in normal mucosa of large intestine and in colorectal tumors. Digestive Diseases and Sciences. ,vol. 46, pp. 2179- 2186 ,(2001) , 10.1023/A:1011910931210
Toni K. Choueiri, Meredith M. Regan, Jonathan E. Rosenberg, William K. Oh, Jessica Clement, Angela M. Amato, David McDermott, Daniel C. Cho, Michael B. Atkins, Sabina Signoretti, Carbonic anhydrase IX and pathological features as predictors of outcome in patients with metastatic clear-cell renal cell carcinoma receiving vascular endothelial growth factor-targeted therapy. BJUI. ,vol. 106, pp. 772- 778 ,(2010) , 10.1111/J.1464-410X.2010.09218.X
Antti J. Kivelä, Seppo Parkkila, Juha Saarnio, Tuomo J. Karttunen, Jyrki Kivelä, Anna-Kaisa Parkkila, Silvia Pastoreková, Jaromir Pastorek, Abdul Waheed, William S. Sly, Hannu Rajaniemi, Expression of transmembrane carbonic anhydrase isoenzymes IX and XII in normal human pancreas and pancreatic tumours. Histochemistry and Cell Biology. ,vol. 114, pp. 197- 204 ,(2000) , 10.1007/S004180000181
Li-fang Ren, Lei Bao, Bo Lu, Hong-guang Cai, Hui-ying Yang, Peng Zhang, Mei-ping Li, Significance of carbonic anhydrase IX protein expression in molecular subtyping of breast cancers Chinese Journal of Pathology. ,vol. 42, pp. 182- 185 ,(2013) , 10.3760/CMA.J.ISSN.0529-5807.2013.03.009
Muneaki Shibakita, Naofumi Nagasue, Reiko Masunaga, Mitsuo Tachibana, Hitoshi Kohno, Dipok Kumar Dhar, Syoichi Kinugasa, Hirofumi Kubota, Satoshi Ohno, Hiroshi Yoshimura, Cyclooxygenase-2 expression correlates with tumor neovascularization and prognosis in human colorectal carcinoma patients Clinical Cancer Research. ,vol. 6, pp. 4064- 4068 ,(2000)
Weiwei Sheng, Ming Dong, Jianping Zhou, Xin Li, Qi Dong, Down regulation of CAII is associated with tumor differentiation and poor prognosis in patients with pancreatic cancer. Journal of Surgical Oncology. ,vol. 107, pp. 536- 543 ,(2013) , 10.1002/JSO.23282
Matthias Choschzick, Egbert Oosterwijk, Volkmar Müller, Linn Woelber, Ronald Simon, Holger Moch, Pierre Tennstedt, Overexpression of carbonic anhydrase IX (CAIX) is an independent unfavorable prognostic marker in endometrioid ovarian cancer Virchows Archiv. ,vol. 459, pp. 193- 200 ,(2011) , 10.1007/S00428-011-1105-Y
A C Klimowicz, P Bose, S K Petrillo, A M Magliocco, J C Dort, N T Brockton, The prognostic impact of a combined carbonic anhydrase IX and Ki67 signature in oral squamous cell carcinoma British Journal of Cancer. ,vol. 109, pp. 1859- 1866 ,(2013) , 10.1038/BJC.2013.533
Seok Jin Kim, Zahid N. Rabbani, Mark W. Dewhirst, Zeljko Vujaskovic, Robin T. Vollmer, Ernst-Gilbert Schreiber, Egbert Oosterwijk, Michael J. Kelley, Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer. Lung Cancer. ,vol. 49, pp. 325- 335 ,(2005) , 10.1016/J.LUNGCAN.2005.03.036
Dina Schütze, Karin Milde-Langosch, Isabell Witzel, Achim Rody, Thomas Karn, Marcus Schmidt, Matthias Choschzick, Fritz Jänicke, Volkmar Müller, None, Relevance of cellular and serum carbonic anhydrase IX in primary breast cancer. Journal of Cancer Research and Clinical Oncology. ,vol. 139, pp. 747- 754 ,(2013) , 10.1007/S00432-013-1378-4