Photodynamic antimicrobial chemotherapy activity of (5,10,15,20-tetrakis(4-(4-carboxyphenycarbonoimidoyl)phenyl)porphyrinato) chloro gallium(III)
作者： Edith K. Amuhaya , Tebello Nyokong , Muthumuni Managa
DOI: 10.1016/J.SAA.2015.06.088
关键词: Solvent 、 Gallium 、 Chemistry 、 Antimicrobial chemotherapy 、 Conjugate 、 Platinum nanoparticles 、 Medicinal chemistry 、 Conjugated system 、 Photochemistry 、 Singlet oxygen 、 Platinum 、 Instrumentation (computer programming) 、 Analytical chemistry 、 Spectroscopy 、 Atomic and Molecular Physics, and Optics
摘要: (5,10,15,20-Tetrakis(4-(4-carboxyphenycarbonoimidoyl)phenyl)porphyrinato) chloro gallium(III) (complex 1) was conjugated to platinum nanoparticles (PtNPs) (represented as 1-PtNPs). The resulting conjugate showed 18 nm red shift in the Soret band when compared 1 alone. Complex and 1-PtNPs promising photodynamic antimicrobial chemotherapy (PACT) activity against Staphylococcus aureus, Escherichia coli Candida albicans solution where log reductions obtained were 4.92, 3.76, 3.95, respectively for 1-PtNPs. singlet oxygen quantum yields higher at 0.56 DMF while that of 0.52 same solvent. This resulted improved PACT
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