A Mathematical Model of Regenerative Axon Growing along Glial Scar after Spinal Cord Injury.

摘要: A major factor in the failure of central nervous system (CNS) axon regeneration is formation glial scar after injury CNS. Glial generates a dense barrier which regenerative axons cannot easily pass through or by. In this paper, mathematical model was established to explore how grow along surface bypass scar. This constructed based on spinal cord (SCI) repair experiments by transplanting Schwann cells as bridge over The Lattice Boltzmann Method (LBM) used for three-dimensional numerical simulation. advantage that it provides parallel and implemented algorithm has capability handling complicated boundaries. Using simulated data, two significant conclusions were made study: (1) levels inhibitory factors are main affecting elongation (2) when remain constant, longitudinal size greater influence average rate growth than transverse size. These results will provide theoretical guidance reference researchers design efficient experiments.