Melatonin administration increases the affinity of D2 dopamine receptors in the rat striatum.
作者： Anwar Hamdi
DOI: 10.1016/S0024-3205(99)80008-3
关键词: Melatonin 、 Receptor 、 Striatum 、 Internal medicine 、 Period (gene) 、 D2 dopamine receptors 、 Rat striatum 、 Da receptors 、 Dopamine 、 Endocrinology 、 Chemistry
摘要: Abstract Rats receive melatonin (MEL) (476 ± 6.5 μg/kg/day) via their drinking water for 2 weeks. At the end of this period, density D2 dopamine (DA) receptors and affinity [ 3 H]-YM-09151-2 are measured in striatum. MEL treatment increases apparent (decreases Kd) DA H]YM-09151-2 by 48%, while it does not significantly alter (Bmax). These findings indicate that striatum is influenced exposure to MEL. The possible implications these results discussed.
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sci-hub.se 参考文章(43)
G.M. Brown, L.P. Niles, Studies on Melatonin and Other Pineal Factors Clinical Neuroendocrinology#R##N#Volume II. pp. 205- 264 ,(1982) , 10.1016/B978-0-12-093602-1.50011-6
D R Sibley, A De Lean, I Creese, Anterior pituitary dopamine receptors. Demonstration of interconvertible high and low affinity states of the D-2 dopamine receptor. Journal of Biological Chemistry. ,vol. 257, pp. 6351- 6361 ,(1982) , 10.1016/S0021-9258(20)65148-1
Andrew Miles, Melatonin: perspectives in the life sciences. Life Sciences. ,vol. 44, pp. 375- 385 ,(1989) , 10.1016/0024-3205(89)90262-2
Peter W. Kalivas, Neurotransmitter regulation of dopamine neurons in the ventral tegmental area Brain Research Reviews. ,vol. 18, pp. 75- 113 ,(1993) , 10.1016/0165-0173(93)90008-N
P.A. Vitte, C. Harthe, P. Pevet, B. Claustrat, Brain autoradiographic study in the golden hamster after intracarotid injection of [14C]melatonin. Neuroscience Letters. ,vol. 110, pp. 1- 5 ,(1990) , 10.1016/0304-3940(90)90777-7
K.H. Al-Zadjali, M.P. Imler, S.E. Ohia, Inhibitory effect of prostaglandins on dopamine release from the retina. General Pharmacology-the Vascular System. ,vol. 25, pp. 289- 296 ,(1994) , 10.1016/0306-3623(94)90057-4
Helen Rosengarten, Jack W. Schweitzer, Arnold J. Friedhoff, Induction of oral dyskinesias in naive rats by D1 stimulation Life Sciences. ,vol. 33, pp. 2479- 2482 ,(1983) , 10.1016/0024-3205(83)90155-8
Lars Farde, Fritz-Axel Wiesel, Christer Halldin, Göran Sedvall, Central D2-Dopamine Receptor Occupancy in Schizophrenic Patients Treated With Antipsychotic Drugs Archives of General Psychiatry. ,vol. 45, pp. 71- 76 ,(1988) , 10.1001/ARCHPSYC.1988.01800250087012
Reuven Sandyk, Hans Fisher, The Protective Function of the Pineal Gland in Tardive Dyskinesia International Journal of Neuroscience. ,vol. 43, pp. 215- 218 ,(1988) , 10.3109/00207458808986172
Per Johansson, Edward Levin, Lars Gunne, Gaylord Ellison, Opposite effects of a D1 and a D2 agonist on oral movements in rats. European Journal of Pharmacology. ,vol. 134, pp. 83- 88 ,(1987) , 10.1016/0014-2999(87)90134-8