Unexplained High BMD in DXA-Scanned Patients is Generalized Throughout the Skeleton and Characterized by Thicker Cortical and Trabecular Bone

摘要: Unexplained high bone mineral density (BMD) is a rare condition and the mechanisms responsible are yet to be described in detail. The aim of study was identify patients with unexplained BMD from local DXA database compare their radiological phenotype an age- gender-matched group population-based controls. We defined as Z-score ≥ + 2.5 at total hip lumbar spine. characterized findings “unexplained” if no osteodegenerative changes, metabolic disease, or arthritis spine observed. All participants were investigated high-resolution peripheral quantitative computed tomography (HR-pQCT), QCT, DXA, fasting blood samples, 24-h urine sample, questionnaires. contained data on 25,118 patients. Initially, 138 (0.55 %) potential identified, during ten additional cases identified new scans. Sixty-seven accepted participate study, among these we 15 women one man BMD. These had higher throughout skeleton relative controls, similar area/volume distal extremities, number trabeculae, which thicker than finite element estimated strength. heavier fat mass then conclude that have generalized skeleton, denser microarchitecture.