Upregulation of PACE4 in prostate cancer is not dependent on E2F transcription factors.
作者： Anita Bakrania , Mélanie Aubé , Roxane Desjardins , Robert Sabbagh , Robert Day
关键词: Gene isoform 、 Downregulation and upregulation 、 Biology 、 Cancer research 、 Transfection 、 Enzyme 、 E2F 、 Proprotein convertase 、 Prostate cancer 、 E2F Transcription Factors
摘要: Recent studies in prostate cancer have identified PACE4, a proprotein convertase enzyme, as an emerging therapeutic target. Inhibition of PACE4-altCT, oncogenic isoform using molecular...
utoronto.ca
nrcresearchpress.com 参考文章(13)
Frédéric Couture, François D'Anjou, Roxane Desjardins, François Boudreau, Robert Day, Role of Proprotein Convertases in Prostate Cancer Progression Neoplasia. ,vol. 14, pp. 1032- 1042 ,(2012) , 10.1593/NEO.121368
Mark A. Castanares, Ben T. Copeland, Wasim H. Chowdhury, Minzhi M. Liu, Ronald Rodriguez, Martin G. Pomper, Shawn E. Lupold, Catherine A. Foss, Characterization of a Novel Metastatic Prostate Cancer Cell Line of LNCaP Origin The Prostate. ,vol. 76, pp. 215- 225 ,(2016) , 10.1002/PROS.23115
François D'Anjou, Sophie Routhier, Jean-Pierre Perreault, Alain Latil, David Bonnel, Isabelle Fournier, Michel Salzet, Robert Day, Molecular Validation of PACE4 as a Target in Prostate Cancer. Translational Oncology. ,vol. 4, pp. 157- 172 ,(2011) , 10.1593/TLO.10295
A. Tsuji, C. Hine, Y. Tamai, K. Yonemoto, K. Mori, S. Yoshida, M. Bando, E. Sakai, K. Mori, T. Akamatsu, Y. Matsuda, Genomic Organization and Alternative Splicing of Human PACE4 (SPC4), Kexin-Like Processing Endoprotease Journal of Biochemistry. ,vol. 122, pp. 438- 452 ,(1997) , 10.1093/OXFORDJOURNALS.JBCHEM.A021772
P.K. Tsantoulis, V.G. Gorgoulis, Involvement of E2F transcription factor family in cancer European Journal of Cancer. ,vol. 41, pp. 2403- 2414 ,(2005) , 10.1016/J.EJCA.2005.08.005
Laurent Chêne, Christiane Giroud, François Desgrandchamps, Laurent Boccon-Gibod, Olivier Cussenot, Philippe Berthon, Alain Latil, Extensive analysis of the 7q31 region in human prostate tumors supports TES as the best candidate tumor suppressor gene. International Journal of Cancer. ,vol. 111, pp. 798- 804 ,(2004) , 10.1002/IJC.20337
Keizo Yuasa, Kaori Suzue, Masami Nagahama, Yoshiko Matsuda, Akihiko Tsuji, Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: Possible role of E2F-mediated upregulation of PACE4 in tumor progression Gene. ,vol. 402, pp. 103- 110 ,(2007) , 10.1016/J.GENE.2007.07.028
J. Gao, B. A. Aksoy, U. Dogrusoz, G. Dresdner, B. Gross, S. O. Sumer, Y. Sun, A. Jacobsen, R. Sinha, E. Larsson, E. Cerami, C. Sander, N. Schultz, Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal Science Signaling. ,vol. 6, pp. 2004088- ,(2013) , 10.1126/SCISIGNAL.2004088
Christopher S Foster, Alison Falconer, Andrew R Dodson, Andrew R Norman, Nening Dennis, Anne Fletcher, Christine Southgate, Anna Dowe, David Dearnaley, Sameer Jhavar, Rosalind Eeles, Andrew Feber, Colin S Cooper, Transcription factor E2F3 overexpressed in prostate cancer independently predicts clinical outcome. Oncogene. ,vol. 23, pp. 5871- 5879 ,(2004) , 10.1038/SJ.ONC.1207800
Ethan Cerami, Jianjiong Gao, Ugur Dogrusoz, Benjamin E Gross, Selcuk Onur Sumer, Bülent Arman Aksoy, Anders Jacobsen, Caitlin J Byrne, Michael L Heuer, Erik Larsson, Yevgeniy Antipin, Boris Reva, Arthur P Goldberg, Chris Sander, Nikolaus Schultz, None, The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data Cancer Discovery. ,vol. 2, pp. 401- 404 ,(2012) , 10.1158/2159-8290.CD-12-0095