Extensive analysis of the 7q31 region in human prostate tumors supports TES as the best candidate tumor suppressor gene.
作者： Laurent Chêne , Christiane Giroud , François Desgrandchamps , Laurent Boccon-Gibod , Olivier Cussenot
DOI: 10.1002/IJC.20337
关键词:
摘要: Loss of heterozygosity (LOH) on chromosome arm 7q31 is found in many prostate tumors. Such alterations are generally associated with inactivation tumor suppressor genes. It has been shown previously that the main region LOH at spans interval between D7S486 and D7S2460 microsatellite loci, which contains several candidate genes (TSG) such as TES, CAV2, CAV1, MET, CAPZA2, ST7 WNT2. We tested 41 human sporadic tumors for by using 5 polymorphic markers overlapping critical used a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay to study expression 7 TSGs located this genomic region. MET TES mRNA was lower than normal tissues. Our immunohistochemical results published data compartmental these messenger RNAs stromal epithelial cells suggest best gene 7q31. © 2004 Wiley-Liss, Inc.
sci-hub.se 参考文章(32)
Jeffrey A. Engelman, Xiao Lan Zhang, Ferruccio Galbiati, Michael P. Lisanti, Chromosomal localization, genomic organization, and developmental expression of the murine caveolin gene family (Cav-1, -2, and -3) FEBS Letters. ,vol. 429, pp. 330- 336 ,(1998) , 10.1016/S0014-5793(98)00619-X
B. J. Wainwright, P. J. Scambler, P. Stanier, E. K. Watson, G. Bell, C. Wicking, X. Estivill, M. Courtney, A. Boue, P. S. Pedersen, ISOLATION OF A HUMAN-GENE WITH PROTEIN-SEQUENCE SIMILARITY TO HUMAN AND MURINE INT-1 AND THE DROSOPHILA SEGMENT POLARITY MUTANT WINGLESS The EMBO Journal. ,vol. 7, pp. 1743- 1748 ,(1988) , 10.1002/J.1460-2075.1988.TB03003.X
M Kamada, M Chikazawa, T Karashima, M Furihata, K Inoue, Y Ohtsuki, T Iiyama, T Shuin, OVEREXPRESSION OF C-MET/HEPATOCYTE GROWTH FACTOR RECEPTORS IN HUMAN PROSTATIC ADENOCARCINOMA Acta Medica Okayama. ,vol. 52, pp. 305- 310 ,(1998) , 10.18926/AMO/31307
T.C. Thompson, T.L. Timme, L. Li, A. Goltsov, Caveolin-1, a metastasis-related gene that promotes cell survival in prostate cancer. Apoptosis. ,vol. 4, pp. 233- 237 ,(1999) , 10.1023/A:1009612708099
Nicola A. Thomas, David Y.H. Choong, Venta J. Jokubaitis, Phillippa J. Neville, Ian G. Campbell, Mutation of the ST7 tumor suppressor gene on 7q31.1 is rare in breast, ovarian and colorectal cancers. Nature Genetics. ,vol. 29, pp. 379- 380 ,(2001) , 10.1038/NG784
Jean C. Zenklusen, Claudio J. Conti, Eric D. Green, Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31. Nature Genetics. ,vol. 27, pp. 392- 398 ,(2001) , 10.1038/86891
Stephen N. Thibodeau, Karen A. Delacey, Michael M. Lieber, David G. Bostwick, Steve R. Ritland, Robert B. Jenkins, Ailin L. Shan, Satoru Takahashi, Frequent Loss of Heterozygosity at 7q31.1 in Primary Prostate Cancer Is Associated with Tumor Aggressiveness and Progression Cancer Research. ,vol. 55, pp. 4114- 4119 ,(1995)
Kate A. Hughes, Adam F.L. Hurlstone, Edward S. Tobias, Robert McFarlane, Donald M. Black, Absence of ST7 mutations in tumor-derived cell lines and tumors Nature Genetics. ,vol. 29, pp. 380- 381 ,(2001) , 10.1038/NG783
Janet C. Thompson, Jacob Kagan, Jean C. Zenklusen, Claudio J. Conti, Patricia Troncoso, Loss of Heterozygosity in Human Primary Prostate Carcinomas: A Possible Tumor Suppressor Gene at 7q31.1 Cancer Research. ,vol. 54, pp. 6370- 6373 ,(1994)
R Lidereau, A Latil, G Fournier, O Cussenot, J C Baron, Loss of heterozygosity at 7q31 is a frequent and early event in prostate cancer. Clinical Cancer Research. ,vol. 1, pp. 1385- 1389 ,(1995)