Expression changes of CAV1 and EZH2, located on 7q31∼q36, are rarely related to genomic alterations in primary prostate carcinoma

摘要: The chromosomal region 7q was repeatedly found to be rearranged in prostate carcinoma. It harbors several well described candidate tumor suppressor and oncogenes. We addressed two genes with opposite roles cancer; CAV1, a putative gene at 7q31, EZH2 7q36, which is believed promote progression. Our primary aim assess their expression changes tumors, then elucidate the underlying mechanism, assuming that genomic alterations of either locus could affect other as well. In 35 samples, compared adjacent tissues, CAV1 overall downregulated (P < 10(-06)), whereas significantly overexpressed 10(-06)). observed dysregulations were coincident nearly 70% cases. Copy number occurred few tumors. Loss DNA only marginally associated reduced = 0.07), however, amplification not explain its upregulation. Through bisulfite sequencing four CpG-hypermethylation verified an alternative mechanism for silencing, reported previously. Moreover, it also involved reactivation EZH2.