The alloantibody response in the allogeneically pregnant rat. III. The location of the alloantibody-forming cells.

摘要: We determined the location of alloantibody formation in allogeneically pregnant rat. Greater than 95% alloantibody-forming cells were found spleen. A few paraaortic, renal, and parathymic lymph nodes. None other lymphomyeloid organs. In addition, vitro synthesis was largely confined to splenic cells. conclude that response rat is peripheral uterus nodes drain uterus. Therefore, cannot be considered an example a local immune response. we confirmed anti-paternal humoral against RT1Aa caused by pregnancies DA males differs dramatically from conventional secondary pregnancy-induced alloimmunizations because hierarchy number alloplaques are developed these four methods detecting different for primary responses as compared with or alloimmunizations.