Chapter 19. Male Contraception

摘要: Publisher Summary At present, voluntary sterilization by vasectomy is the most commonly used method of male contraception despite drawbacks its surgical nature and nonreversibility. While physical methods continue to be prevalent form contraception, efficacious safe chemical are under active investigation. Strategies that include inhibition sperm maturation in epididymis or direct interference with spermatogenic cells have not been generally successful because unacceptable toxic side-effects. There optimism for small molecule approach. Progestins, anti-estrogens, androgens as well various combinations these three all alter fertility male. This an area research allows quick entry into human clinical trials comfort level working compounds known toxicity, many which women years. Direct spermatogenesis, through suppression secretion gonadotrophins, must combined replacement testosterone. These use progestogens LH-releasing hormone antagonists testosterone derivatives high dose Though effective can obtained, using steroid therapy, side-effects, and/or cost treatment limit widespread approaches. Other approaches antibodies follicle stimulating (FSH), surface proteins, epididimal proteins has provided a fruitful research. Apart from this, peptide hormones (LH-RH, FSH) their analogs major study but effectiveness therapies somewhat controversial.