Maintenance of genome stability: the unifying role of interconnections between the DNA damage response and RNA-processing pathways.

作者: B. Mikolaskova , M. Jurcik , I. Cipakova , M. Kretova , M. Chovanec

DOI: 10.1007/S00294-018-0819-7

关键词: Crosstalk (biology)DNA damageDNA repairRNA splicingGenome instabilityGene expressionCell biologyCell cycleBiologyProteomics

摘要: Endogenous and exogenous factors can severely affect the integrity of genetic information by inducing DNA damage impairing genome stability. The protection is ensured so-called “DNA response” (DDR), a set evolutionary-conserved events that, triggered upon detection, arrests cell cycle, attempts repair. Here, we review role DDR proteins as post-transcriptional regulators gene expression, in addition to their roles recognition, signaling, At same time, discuss recent insights into how pre-mRNA splicing go beyond activities play direct functions detecting, repairing damage. importance extensive two-way crosstalk interaction between RNA processing stems from growing evidence that defects communication lead genomic instability.

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