作者: B. Mikolaskova , M. Jurcik , I. Cipakova , M. Kretova , M. Chovanec
DOI: 10.1007/S00294-018-0819-7
关键词: Crosstalk (biology) 、 DNA damage 、 DNA repair 、 RNA splicing 、 Genome instability 、 Gene expression 、 Cell biology 、 Cell cycle 、 Biology 、 Proteomics
摘要: Endogenous and exogenous factors can severely affect the integrity of genetic information by inducing DNA damage impairing genome stability. The protection is ensured so-called “DNA response” (DDR), a set evolutionary-conserved events that, triggered upon detection, arrests cell cycle, attempts repair. Here, we review role DDR proteins as post-transcriptional regulators gene expression, in addition to their roles recognition, signaling, At same time, discuss recent insights into how pre-mRNA splicing go beyond activities play direct functions detecting, repairing damage. importance extensive two-way crosstalk interaction between RNA processing stems from growing evidence that defects communication lead genomic instability.