Interfaces Between the Detection, Signaling, and Repair of DNA Damage

摘要: Left unrepaired, the myriad types of damage that can occur in genomic DNA pose a serious threat to faithful transmission correct complement genetic material. Defects signaling and repair result instability, hallmark cancer, often cause lethality, underlining importance these processes cell whole organism. The past decade has seen huge advances our understanding how signal transduction pathways triggered by radically alter behavior. In contrast, it is still unclear primary detected this interfaces with proteins.