Yap-dependent reprogramming of Lgr5 + stem cells drives intestinal regeneration and cancer
作者： Alex Gregorieff , Yu Liu , Mohammad R. Inanlou , Yuliya Khomchuk , Jeffrey L. Wrana
DOI: 10.1038/NATURE15382
关键词: Stem cell 、 Biology 、 Cell biology 、 Intestinal epithelium 、 Epiregulin 、 Paneth cell 、 Hedgehog signaling pathway 、 Regeneration (biology) 、 Wnt signaling pathway 、 LGR5
摘要: … elevated Wnt contributes to these phenotypes, we lowered Wnt signalling in Yap … Wnt signalling also rescues Yap Δ/Δ crypts in vitro, our results suggest that in vivo Yap coordinates Wnt …
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