Diagnostic accuracy and impact on management of 18 F-FDG PET and PET/CT in colorectal liver metastasis: a meta-analysis and systematic review

摘要: The first aim of the review (aim 1) was to obtain diagnostic performance values 18F-FDG PET for detection and staging liver metastases in patients with colorectal cancer (CRC), second 2) compare conventional imaging modalities, third 3) evaluate impact on patient management. incidence extrahepatic disease (EHD) detected by is also reviewed. A comprehensive search performed PubMed/MEDLINE studies evaluating PET/CT CRC up June 2014. For inclusion had have been prior surgery, there be at least 18 study, reported data allow calculation 2 × 2 contingency tables (for 1). total were eligible one three intended subanalyses including a 1,059 patients. Pooled sensitivity, specificity accuracy corresponding 95 % confidence intervals derived from basis (patient-based analysis, PBA) lesion (lesion-based LBA) eight studies. sensitivity PBA both 93 %. Corresponding LBA 60 % 79 %, respectively. Areas under summary ROC 0.97 0.67 LBA. Regarding 2, slightly lower than MRI CT (93 %, 100 % 98 %, respectively) (66 %, 89 % but appeared more specific (86 %, 81 % 67 %, respectively). findings resulted changes management mean 24 % PET-based EHD 32 %. This meta-analysis suggests that FDG highly accurate less basis. Compared MRI, sensitive affects about one-quarter