Association between HindIII (rs320) variant in the lipoprotein lipase gene and the presence of coronary artery disease and stroke among the Saudi population.

摘要: Abstract Lipoprotein Lipase (LPL) is known to be a key enzyme for lipid metabolism specifically in an enzymatic glycoprotein which provide tissues without fatty-acids and eliminates triglycerides (TG) by the circulation. Mutations LPL were proven cause alteration fractions within lipoprotein, causing development of atherosclerosis predispose weakening coronary artery disease (CAD) stroke. We examined linkage between genetic variant HindIII on lipoprotein fractions, stroke occurrences CAD. In this case-control study, we have recruited 315 CAD cases 205 age-matched controls. A total 520 genomic DNA was digested with purified PCR products restriction fragment length polymorphism enzyme. The distribution genotypes decreasing order TT, 148 (47%), GT 135 (42.9%) GG 32 (10.2%) groups study while pattern controls 91 (44.4%), TT 86 (42%) 28 (13.7%). None all allele or genotype frequencies found significant our (p greater than 0.05), biochemical levels both TG LDL-c shown prone patients when compare Furthermore, occurence strokes more vs. controls: 72 (22.9%) 7 (3.4%) [p 0.000]. This could indicate influence plasma levels, possibility considering it risk factor leading occurrence.