Correlation between KCNQ1 and KCNJ11 gene polymorphisms and type 2 and post-transplant diabetes mellitus in the Asian Indian population

摘要: Type 2 diabetes mellitus (T2DM) and post-transplant (PTDM) share a common pathophysiology. However, is complex disease, T2DM PTDM have different etiologies. metabolic disorder, characterized by persistent hyperglycemia, whereas condition of abnormal glucose tolerance, with variable onset after organ transplant. The KCNQ1 KCNJ11 gene encode potassium channels, which mediate insulin secretion from pancreatic β-cells, KCN mutations are correlated the development diabetes. no studies been carried out to establish an association between polymorphisms PTDM. Therefore, our study was aimed at identification role associated risk developing in Asian Indian population. We case-control including 250 patients T2DM, control subjects, 42 98 subjects non-PTDM. PCR-RFLP analysis following isolation genomic DNA EDTA-blood samples. results present reveal that two single nucleotide (rs2283228 rs5210, genes, respectively) both suggest variants increased