Importance of glucokinase -258G/A polymorphism in Asian Indians with post-transplant and type 2 diabetes mellitus.
作者： Imran Ali Khan , Kiran Kumar Vattam , Parveen Jahan , Qurratulain Hasan , Pragna Rao
关键词:
摘要: Type 2 diabetes mellitus (T2DM) and post-transplant (PTDM) are non-synonymous forms of diabetes. Glucokinase (GCK) plays a key role in glucose metabolism. The relationship between the GCK promoter specific types diabetes, such as PTDM T2DM, Asian Indian population is unknown. We examined occurrence variant (-258G/A) patients with T2DM PTDM. case-control study enrolled 640 subjects, including controls (n = 250) 250), 42), non-post-transplant (non-PTDM) 98) patients. Purified Deoxyribonucleic acid (DNA) was genotyped polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) analysis. digested PCR products were analyzed on 12% polyacrylamide gels. anthropometric, biochemical, clinical details each group documented. -258G/A alleles genotypes not associated T2DM. However, among we detected higher frequency heterozygotes (52.4%) positive association alleles/genotypes. results suggest that region an important Indians.
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