Familial aggregation of type 2 diabetes and chronic hypertension in women with gestational diabetes mellitus.

摘要: Objective To perform a case-control study to assess the extent which women with positive parental history of type 2 diabetes and/or chronic hypertension experienced an increased risk developing gestational mellitus (GDM). Study design Participants (133 GDM cases and 373 controls) provided information on first-degree family conditions other covariates interest in interviews. Logistic regression procedures were used derive odds ratios 95% confidence intervals adjusted for confounding by maternal age, race/ethnicity prepregnancy adiposity. Results As compared no diabetes, maternal-only (odds ratio = 2.0), paternal-only 2.3) or both paternal 3.8) statistically significant GDM. The was 2.6 (95% interval, 1.3-5.3). Women diabetic sibling had 8.4-fold 2.1-33.4). First-degree predictive but only when associated diagnosis diabetes. Conclusion Our results are consistent thesis that (alone hypertension) reflects genetic behavioral factors whereby may be predisposed risk.