Circulating lncRNAs associated with occurrence of colorectal cancer progression
作者： Jian Shi , Changxi Zhang , Sanyuan Hu , Xiaohua Li , Qiangpu Chen
DOI:
关键词: Colorectal cancer 、 Potential biomarkers 、 Cancer research 、 Early detection 、 Carcinogenesis 、 Biomarker (medicine) 、 Framingham Risk Score 、 Medicine 、 Microarray 、 Training set
摘要: Screening for the potential biomarker of colorectal cancer (CRC) is necessary to improve early detection. The aim this study was investigate circulating cell-free long non-coding RNAs (lncRNA) as biomarkers CRC. In study, we applied an lncRNA microarray screen CRC with a multi-stage validation and risk score formula We discovered three lncRNA, XLOC_006844, LOC152578 XLOC_000303, which were up-regulated in comparing cancer-free controls merged area under curve (AUC) training set 0.919 0.975. lncRNAs might be tumorigenesis prediction future.
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