Medullary thyroid cancer. An immunohistochemical and humoral study using six separate antigens.

摘要: The authors investigated the humoral and tissue expression of six antigens associated with medullary thyroid cancer (MTC): calcitonin (CT), gene-related peptide (CGRP), carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), somatostatin (SRIF), thyroglobulin (TG). were studied in neoplastic C cells using immunohistochemistry specific antisera plasma radioimmunoassay. Eighteen patients (8 male 10 female patients, aged 12-72 years) studied. Mean follow-up was 70.7 months (range, 2-179 months). Nine (50%) died their disease after a mean 47.2 2-116 By immunostaining, primary tumors expressed CT CEA all cases NSE positive 90%, CGRP 66%, SRIF 63%, TG 58%. Metastatic tissues staining, 92.8% CEA, 71.4% NSE, 73.3% CGRP, 38.5% SRIF, only 13.3% staining. In percentage degree staining variable among different antigens. an hypersecretion corresponding circulation case CEA. levels these elevated metastases could accurately predict appearance new or indicate effective treatment previous by surgery. few had increased concentrations usually occurred during very advanced phases disease. Detectable serum never observed. When outcome compared CT, TG, no correlation be found. On contrary, tumor differentiate two groups survival rates. SRIF-positive rates 100% 50% at five seven years, respectively, whereas SRIF-negative 40% years 25% years.