Murine Gammaherpesvirus 68 Infection of Mice: A Small Animal Model for Characterizing Basic Aspects of Gammaherpesvirus Pathogenesis

摘要: The human gammaherpesviruses, EBV and KSHV, have a narrow host range, limiting development of small animal models for characterizing aspects KSHV pathogenesis. As such, over the past 15 years there has been increasing interest in studying murine gammaherpesvirus 68 (γHV68, MHV68) infection inbred strains laboratory mice. In this chapter, we review advances model system how these findings may offer insights into infections humans.