Early Establishment of γ-Herpesvirus Latency: Implications for Immune Control

摘要: The human γ-herpesviruses, EBV and Kaposi’s sarcoma-associated herpesvirus, infect >90% of the population worldwide, latent infection is associated with numerous malignancies. Rational vaccination therapeutic strategies require an understanding virus-host interactions during initial asymptomatic infection. Primary virus replication at epithelial sites entry into circulating B lymphocyte pool. exploits life cycle cell latency maintained long term in resting memory cells. In this study, using a murine γ-herpesvirus model, we demonstrate early dominance site infection, lung cells harboring almost immediately after These data reinforce central role not only later phase but Early inhibition lytic does impact progression established lymphoid tissues following replication-deficient mutant virus. that viral requirement for vivo suggest can be disseminated by cellular proliferation. observations emphasize prophylactic must target