A global analysis of adaptive evolution of operons in cyanobacteria.
作者： Danish Memon , Abhay K. Singh , Himadri B. Pakrasi , Pramod P. Wangikar
DOI: 10.1007/S10482-012-9813-0
关键词: Horizontal gene transfer 、 Phylogenetics 、 Clade 、 Intergenic region 、 Operon 、 Biology 、 Gene 、 Genetics 、 Comparative genomics 、 Genome
摘要: Operons are an important feature of prokaryotic genomes. Evolution operons is hypothesized to be adaptive and has contributed significantly towards coordinated optimization functions. Two conflicting theories, based on (i) in situ formation achieve co-regulation (ii) horizontal gene transfer functionally linked clusters, generally considered explain why how have evolved. Furthermore, effects operon evolution genomic traits such as intergenic spacing, size relatively less explored. Based the conservation level a set diverse prokaryotes, we categorize operonic pair associations turn ancient recently formed. This allowed us perform detailed analysis structure cyanobacteria, morphologically physiologically group photoautotrophs. Clustering showed significant similarity with 16S rRNA-based phylogeny, which groups cyanobacterial strains into three clades. Clade C, dominated by that believed undergone genome reduction, shows larger fraction genes tightly packed sized operons. Ancient general larger, more packed, better optimized for part key cellular processes. A sub-clade within B, includes Synechocystis sp. PCC 6803, reverse trend spacing. Our results suggest while vertical descent may dominant mechanism spacing ongoing process life-cycle
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