Some General Properties of Excitable Tissues

作者: Clay M. Armstrong

DOI: 10.1007/978-1-4613-3958-8_25

关键词: BiophysicsSecretionHeartbeatMembrane potentialHeart cellsGiant axonVoltage clampCellContractile apparatusChemistry

摘要: This chapter is about electrical signaling in cells, how it works, and may have evolved. All animal cells a membrane potential, specialized properties developed many. Axons, for example, serve as carriers of digital impulses over long distances. In heart the permeability are timing devices to control rate heartbeat. The contractile apparatus muscle fibers under control, activated when potential exceeds threshold value. Secretion transmitters, possibly hormones, triggered by changes. intestinal aids uptake glucose amino acids. uses cell electricity make an endless list, one moved ask all came about. Clearly, nature cannot foreseen these applications at outset, so why did potentials develop begin with? answer seems lie necessity osmotic equilibrium cells.(1)

参考文章(10)
Joseph F. Hoffman, The cellular functions of membrane transport Prentice-Hall. ,(1964)
A. L. Hodgkin, A. F. Huxley, A quantitative description of membrane current and its application to conduction and excitation in nerve The Journal of Physiology. ,vol. 117, pp. 500- 544 ,(1952) , 10.1113/JPHYSIOL.1952.SP004764
W K Chandler, H Meves, Voltage clamp experiments on internally perfused giant axons. The Journal of Physiology. ,vol. 180, pp. 788- 820 ,(1965) , 10.1113/JPHYSIOL.1965.SP007732
A. L. Hodgkin, A. F. Huxley, B. Katz, Measurement of current‐voltage relations in the membrane of the giant axon of Loligo The Journal of Physiology. ,vol. 116, pp. 424- 448 ,(1952) , 10.1113/JPHYSIOL.1952.SP004716
Clay M. Armstrong, Francisco Bezanilla, Eduardo Rojas, Destruction of sodium conductance inactivation in squid axons perfused with pronase. The Journal of General Physiology. ,vol. 62, pp. 375- 391 ,(1973) , 10.1085/JGP.62.4.375
A. L. Hodgkin, P. Horowicz, The influence of potassium and chloride ions on the membrane potential of single muscle fibres The Journal of Physiology. ,vol. 148, pp. 127- 160 ,(1959) , 10.1113/JPHYSIOL.1959.SP006278
S. H. Bryant, A. Morales-Aguilera, Chloride conductance in normal and myotonic muscle fibres and the action of monocarboxylic aromatic acids The Journal of Physiology. ,vol. 219, pp. 367- 383 ,(1971) , 10.1113/JPHYSIOL.1971.SP009667
John W. Moore, Mordecai P. Blaustein, Nels C. Anderson, Toshio Narahashi, Basis of tetrodotoxin's selectivity in blockage of squid axons. The Journal of General Physiology. ,vol. 50, pp. 1401- 1411 ,(1967) , 10.1085/JGP.50.5.1401
Kenneth S. Cole, John W. Moore, Ionic Current Measurements in the Squid Giant Axon Membrane The Journal of General Physiology. ,vol. 44, pp. 123- 167 ,(1960) , 10.1085/JGP.44.1.123
Clay M. Armstrong, Francisco Bezanilla, Charge Movement Associated with the Opening and Closing of the Activation Gates of the Na Channels The Journal of General Physiology. ,vol. 63, pp. 533- 552 ,(1974) , 10.1085/JGP.63.5.533