II. Preparación de nuevas fenilamidas anticonvulsionantes
作者： Guillermo Carvajal-Sandoval , Sergio Enrique Meza-Toledo
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摘要: En el presente trabajo se prepararon una serie nueva de fenilamidas anticonvulsionantes conteniendo los grupos trifluorometilo, fluor, bromo y cloro en anillo aromatico compuestos DL-2- hidroxi-2-etil-2-fenil acetamida (DL-HEPA), DL-3-hidroxi-3-etil- 3-fenilpropionamida (DL-HEPP) DL-4-hidroxi-4-etil-4-fenilbutiramida (DL-HEPB). Los preparados presentaron actividad anticonvulsionante bastante significativa contra las convulsiones la muerte provocadas por metrazol ratones. La incorporacion halogenos DL-HEPA, DL-HEPP DL-HEPB condujo a con similar del fenobarbital. Se presentan evidencias que preparadas podrian actuar como antagonistas receptores GABA.
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