Ionotropic GABA Receptors as Therapeutic Targets for Memory and Sleep Disorders

摘要: Publisher Summary γ-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the brain. GABA produces neuronal inhibition by acting on two types of receptors: ionotropic receptors that are ligand-gated ion channels (GABA A and C receptors), metabotropic G-protein coupled B receptors) act via second messengers. This chapter focuses as therapeutic targets particular for memory sleep disorders. The belong to nicotinicoid superfamily includes nicotinic acetylcholine, strychnine-sensitive glycine 5HT 3 receptors. Structurally, similar other members channels, consisting five protein subunits arranged around central pore constitutes actual channel. Agents or have widespread potential including therapy discovery selective receptor agents modulators allosteric sites agonists, partial agonists antagonists orthosteric, site challenge continuing development specific subtypes