Bevacizumab in Combination With Oxaliplatin-Based Chemotherapy As First-Line Therapy in Metastatic Colorectal Cancer: A Randomized Phase III Study

作者: Leonard B. Saltz , Stephen Clarke , Eduardo Díaz-Rubio , Werner Scheithauer , Arie Figer

DOI: 10.1200/JCO.2007.14.9930

关键词: OncologyColorectal cancerFOLFIRIOxaliplatinBevacizumabInternal medicineFolinic acidCapecitabineSurgeryFOLFOXIRIFOLFOXMedicineCancer research

摘要: Purpose To evaluate the efficacy and safety of bevacizumab when added to first-line oxaliplatin-based chemotherapy (either capecitabine plus oxaliplatin [XELOX] or fluorouracil/folinic acid plus oxaliplatin [FOLFOX-4]) in patients with metastatic colorectal cancer (MCRC).

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