A Novel Function for Galectin-1 at the Crossroad of Innate and Adaptive Immunity: Galectin-1 Regulates Monocyte/Macrophage Physiology through a Nonapoptotic ERK-Dependent Pathway

作者: Paula Barrionuevo , Macarena Beigier-Bompadre , Juan M. Ilarregui , Marta A. Toscano , Germán A. Bianco

DOI: 10.4049/JIMMUNOL.178.1.436

关键词: Immune systemMAPK/ERK pathwayMonocytePhysiologyAntigen presentationAcquired immune systemInflammationT cellCell biologyMacrophageBiology

摘要: Several environmental factors can differentially regulate monocyte and macrophage response patterns, resulting in the display of distinct functional phenotypes. Galectin-1, an endogenous lectin found at peripheral lymphoid organs inflammatory sites, has shown immunoregulatory activity vivo experimental models autoimmunity cancer. Whereas compelling evidence been accumulated regarding effects galectin-1 on T cell fate, limited information is available how may impact other immune types. In present study, we report a novel role for regulation physiology. Treatment with vitro regulates constitutive inducible FcγRI expression human monocytes FcγRI-dependent phagocytosis. addition, inhibits IFN-γ-induced MHC class II (MHC-II) MHC-II-dependent Ag presentation dose-dependent manner. These regulatory were also evident mouse macrophages recruited to stimuli following treatment recombinant further confirmed galectin-1-deficient mice. Investigation mechanisms involved these functions showed that does not affect survival monocytes, but rather influences FcγRI- through active involving modulation ERK1/2-dependent pathway. Our results provide unrecognized control monocyte/macrophage physiology potential implications crossroad innate adaptive immunity.

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