Endogenous Galectin-1 and Acute Inflammation: Emerging Notion of a Galectin-9 Pro-Resolving Effect

摘要: The role of endogenous galectin-1 (Gal-1) in acute inflammation has been poorly investigated. We therefore performed the carrageenan-induced paw edema model wild-type and Gal-1−/− mice. On subplantar injection carrageenan, mice displayed a similar first phase (≤24 hours) to mice; however, much less pronounced second (48 96 was evident this genotype. This reduced associated with lower expression inflammatory genes cell infiltrates. Analysis galectin protein mRNA revealed high Gal-1 paws during resolution (≥48 hours), some galectin-9 (Gal-9). Administration stable completely ablated but ineffective when administered therapeutically at 24-hour time point. Conversely, Gal-9 administration did not alter significantly therapeutically. suggests anti-inflammatory actions for both proteins albeit different phases response. Collectively, these data indicate that absence results an abrogated response reaction.