DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia

Saul J. Sharkis, Stephen B. Baylin, Jean Pierre J. Issa, James G. Herman, Curt I. Civin, Michael I. Collector, Distinct Patterns of Inactivation of p15INK4B and p16INK4A Characterize the Major Types of Hematological Malignancies Cancer Research. ,vol. 57, pp. 837- 841 ,(1997)

Myunggon Ko, Yun Huang, Anna M. Jankowska, Utz J. Pape, Mamta Tahiliani, Hozefa S. Bandukwala, Jungeun An, Edward D. Lamperti, Kian Peng Koh, Rebecca Ganetzky, X. Shirley Liu, L. Aravind, Suneet Agarwal, Jaroslaw P. Maciejewski, Anjana Rao, Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2 Nature. ,vol. 468, pp. 839- 843 ,(2010) , 10.1038/NATURE09586

Guido Marcucci, Kati Maharry, Michael D. Radmacher, Krzysztof Mrózek, Tamara Vukosavljevic, Peter Paschka, Susan P. Whitman, Christian Langer, Claudia D. Baldus, Chang-Gong Liu, Amy S. Ruppert, Bayard L. Powell, Andrew J. Carroll, Michael A. Caligiuri, Jonathan E. Kolitz, Richard A. Larson, Clara D. Bloomfield, Prognostic Significance of, and Gene and MicroRNA Expression Signatures Associated With,CEBPAMutations in Cytogenetically Normal Acute Myeloid Leukemia With High-Risk Molecular Features: A Cancer and Leukemia Group B Study Journal of Clinical Oncology. ,vol. 26, pp. 5078- 5087 ,(2008) , 10.1200/JCO.2008.17.5554

James G. Herman, Stephen B. Baylin, Gene Silencing in Cancer in Association with Promoter Hypermethylation The New England Journal of Medicine. ,vol. 349, pp. 2042- 2054 ,(2003) , 10.1056/NEJMRA023075

Jana Marie Schwarz, Christian Rödelsperger, Markus Schuelke, Dominik Seelow, MutationTaster evaluates disease-causing potential of sequence alterations Nature Methods. ,vol. 7, pp. 575- 576 ,(2010) , 10.1038/NMETH0810-575

Maria E. Figueroa, Omar Abdel-Wahab, Chao Lu, Patrick S. Ward, Jay Patel, Alan Shih, Yushan Li, Neha Bhagwat, Aparna Vasanthakumar, Hugo F. Fernandez, Martin S. Tallman, Zhuoxin Sun, Kristy Wolniak, Justine K. Peeters, Wei Liu, Sung E. Choe, Valeria R. Fantin, Elisabeth Paietta, Bob Löwenberg, Jonathan D. Licht, Lucy A. Godley, Ruud Delwel, Peter J.M. Valk, Craig B. Thompson, Ross L. Levine, Ari Melnick, Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. ,vol. 18, pp. 553- 567 ,(2010) , 10.1016/J.CCR.2010.11.015

Hagop Kantarjian, Jean-Pierre J. Issa, Craig S. Rosenfeld, John M. Bennett, Maher Albitar, John DiPersio, Virginia Klimek, James Slack, Carlos de Castro, Farhad Ravandi, Richard Helmer, Lanlan Shen, Stephen D. Nimer, Richard Leavitt, Azra Raza, Hussain Saba, Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer. ,vol. 106, pp. 1794- 1803 ,(2006) , 10.1002/CNCR.21792

W. Blum, R. Garzon, R. B. Klisovic, S. Schwind, A. Walker, S. Geyer, S. Liu, V. Havelange, H. Becker, L. Schaaf, J. Mickle, H. Devine, C. Kefauver, S. M. Devine, K. K. Chan, N. A. Heerema, C. D. Bloomfield, M. R. Grever, J. C. Byrd, M. Villalona-Calero, C. M. Croce, G. Marcucci, Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 7473- 7478 ,(2010) , 10.1073/PNAS.1002650107

Y Yamashita, J Yuan, I Suetake, H Suzuki, Y Ishikawa, Y L Choi, T Ueno, M Soda, T Hamada, H Haruta, S Takada, Y Miyazaki, H Kiyoi, E Ito, T Naoe, M Tomonaga, M Toyota, S Tajima, A Iwama, H Mano, Array-based genomic resequencing of human leukemia Oncogene. ,vol. 29, pp. 3723- 3731 ,(2010) , 10.1038/ONC.2010.117

Lewis R. Silverman, Erin P. Demakos, Bercedis L. Peterson, Alice B. Kornblith, Jimmie C. Holland, Rosalie Odchimar-Reissig, Richard M. Stone, Douglas Nelson, Bayard L. Powell, Carlos M. DeCastro, John Ellerton, Richard A. Larson, Charles A. Schiffer, James F. Holland, Randomized Controlled Trial of Azacitidine in Patients With the Myelodysplastic Syndrome: A Study of the Cancer and Leukemia Group B Journal of Clinical Oncology. ,vol. 20, pp. 2429- 2440 ,(2002) , 10.1200/JCO.2002.04.117