Which HIV-infected youth are at risk of developing depression and what treatments help? A systematic review focusing on Southern Africa

摘要: Background Depression is common in people with HIV and associated lower quality of life, reduced medication adherence, worse disease progression higher risk transmission to others. While the majority HIV-infected youth live Southern Africa, research has largely focused on adults from Western countries, limited generalisability across these populations. This review sought identify synthesise factors for depression summarise available evidence psychosocial interventions reduce depression. Method A systematic was conducted studies using a validated measure (aged ≤19) Africa. Eligible included either analysis variables depression, or evaluation impact this population. Results Twelve met inclusion criteria assessing factors, based nine independent samples, constituting 3573 9-19 years). Study varied, heterogeneous methodology limiting comparability conclusions. There some that female gender, older age, food insecurity, exposure abuse internalised stigma are while disclosure status, satisfaction relationships social support protective. Only one study (n = 65; aged 10-13 The intervention did not successfully demonstrating need low-cost, large scale be developed trialled. Conclusion highlighted dearth into Disclosing status could an important protective factor.