Suppression of adoptive antibody responses by addition of spleen cells from agammaglobulinaemic chickens "immunised" with histocompatible bursa cells.

摘要: THE report that T cells from patients with common variable hypogammaglobulinaemia can suppress immunoglobulin synthesis by B in vitro1 implies some forms of could, at least part, be maintained a patient's own cells. Blaese et al.2 described phenomenon “infectious agammaglobulinaemia” line 6 chickens (USDA Regional Poultry Research Laboratory, East Lansing) which seems to represent an ideal laboratory model for the human disease. Transfer agammaglobulinaemia spleen has now also been observed consistently strain FP and SC chickens22. The mechanism whereby recipients agammaglobulinaemic donor are rendered is, however, difficult analyse such long term vivo system. Thus, further examination would greatly facilitated short assay allow better identification target cell.