Transfer of agammaglobulinemia in the chicken

摘要: Abstract Spleen cells from adult agammaglobulinemic (bursectomized) chickens taken 1 to 3 weeks after an injection of histocompatible bursa can inhibit the adoptive antibody response B. abortus normal spleen or in irradiated recipients. Aγ not injected with generally do not. Moreover, bursectomized which have been reconstituted within first week hatching respond suppressor cell formation upon injection. This apparent “autoimmunization” induces T are only minimally sensitive treatment mitomycin C 5000 R γ irradiation. The activity is neither induced nor potentiated by concanavalin A vivo. It much stronger than thymus and appears be macrophage independent require intact cells. component stimulates more pronounced on cells, at most present a very limited extent bone marrow, thymus, peritoneal exudate better represented comparable numbers Day 17 14 embryonic bursa. inducing membrane fraction disrupted Immunization B locus histoincompatible leads against Although removal Ig-bearing greatly diminishes its immunizing capacity, serum IgM IgG does induce suggested that tolerance B-cell antigen lacking chickens, resulting autoimmune exposure may surface-specific form Ig, complex Ig component, differentiation simultaneously during ontogeny.