In vitro activity of two old antibiotics against clinical isolates of methicillin-resistant Staphylococcus aureus
作者： Xu-Hong Yu , Xiu-Jie Song , Yun Cai , Bei-Bei Liang , De-Feng Lin
DOI: 10.1038/JA.2010.105
关键词: Staphylococcus aureus 、 Antagonism 、 Biology 、 Fusidic acid 、 Staphylococcal infections 、 Drug resistance 、 Methicillin-resistant Staphylococcus aureus 、 Fosfomycin 、 Microbiology 、 Antibiotics
摘要: The objective of this paper was to investigate the in vitro effects fusidic acid combined with fosfomycin against methicillin-resistant Staphylococcus aureus (MRSA). In all, 196 MRSA strains isolated from three clinical specimens human infections hospitals China were used study. checkerboard method determine whether combinations act synergistically these strains. susceptibility results for and interpreted according guidelines Clinical Laboratory Standards Institute. combination demonstrated following interactions: 87.76% (172/196) synergism, 12.24% (24/196) indifference no antagonism seen (minimum maximum fractional inhibitory concentration index 0.14 0.75, respectively). Thus, show synergism most isolates tested study, may be a future therapeutic alternative caused by MRSA.
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