Fusidic acid in the treatment of methicillin-resistant Staphylococcus aureus.

作者: Michael Whitby

DOI: 10.1016/S0924-8579(98)00075-2

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摘要: The emergence of MRSA in the 1960s coincided with introduction fusidic acid. Since that time, antibiotic has been widely used against this organism, both and 1970s more modern multi-resistant version 1980s 1990s. Although showing potent vitro activity, experimental vivo investigations have demonstrated disappointing results. Clinical efficacy a series small studies case reports, particularly when acid is combination for treatment carriage. Given widespread use MRSA, published evidence supporting its limited does not support agent as monotherapy.

参考文章(20)
R.A. Cox, C. Mallaghan, C. Conquest, J. King, Epidemic methicillin-resistant Staphylococcus aureus: controlling the spread outside hospital Journal of Hospital Infection. ,vol. 29, pp. 107- 119 ,(1995) , 10.1016/0195-6701(95)90192-2
J. M. BESNIER, F. KANOUN, C. MARTIN, P. COTTY, A. FENNETEAU, P. CHOUTET, Failure of a combination of vancomycin and fusidic acid in a patient with staphylococcal infection Journal of Antimicrobial Chemotherapy. ,vol. 27, pp. 560- 562 ,(1991) , 10.1093/JAC/27.4.560
Joel Unowsky, Pranatharth H. Chandrasekar, William DeLorenzo, Donald P. Levine, In vitro and in vivo activity of coumermycin and other antibacterial agents against methicillin-resistant strains of Staphylococcus aureus Chemotherapy. ,vol. 32, pp. 499- 505 ,(1986) , 10.1159/000238459
J. WEBSTER, J. L. FAOAGALI, D. CARTWRIGHT, Elimination of methicillin-resistant Staphylococcus aureus from a neonatal intensive care unit after hand washing with triclosan Journal of Paediatrics and Child Health. ,vol. 30, pp. 59- 64 ,(1994) , 10.1111/J.1440-1754.1994.TB00568.X
J.A. O'Garra, Methicillin-resistant staphylococci. The Lancet. ,vol. 292, pp. 1037- 1038 ,(1968) , 10.1016/S0140-6736(68)91332-9
TANIA C SORRELL, DONALD R PACKHAM, SIVARAJ SHANKER, MARY FOLDES, ROSEMARY MUNRO, Vancomycin Therapy for Methicillin-Resistant Staphylococcus aureus Annals of Internal Medicine. ,vol. 97, pp. 344- 350 ,(1982) , 10.7326/0003-4819-97-3-344
Klaus Jensen, METHICILLIN-RESISTANT STAPHYLOCOCCI The Lancet. ,vol. 292, pp. 1078- ,(1968) , 10.1016/S0140-6736(68)91549-3
P. H. Blakemore, S. Mehtar, Y. J. Drabu, B. Walsh, Teicoplanin in infections caused by methicillin-resistant staphylococci Journal of Antimicrobial Chemotherapy. ,vol. 21, pp. 89- 92 ,(1988) , 10.1093/JAC/21.SUPPL_A.89
F. Parras, M. C. Guerrero, E. Bouza, M. J. Blazquez, S. Moreno, M. C. Menarguez, E. Cercenado, Comparative study of mupirocin and oral co-trimoxazole plus topical fusidic acid in eradication of nasal carriage of methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. ,vol. 39, pp. 175- 179 ,(1995) , 10.1128/AAC.39.1.175