Antimicrobial susceptibility pattern of clinical isolates of methicillin resistant Staphylococcus aureus.

作者: Qamaruddin Barakzi , Nasim Sabir , Samia Perwaiz , Badar Jehan Farooqi , Nazia Khursheed

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摘要: OBJECTIVE: To study the antimicrobial susceptibility pattern of MRSA isolates from patients in a tertiary care hospital. METHODS: This was in-vitro on received clinical samples department microbiology during one year (March 2004-February 2005). All were processed by conventional method using sheep blood agar, MacConkey's agar and Chocolate plates. Staphylococci identified catalase, coagulase D'nase tests. Antimicrobial testing all performed Mueller-Hinton plates modified Kirby Bauer's Disc Diffusion method. The disc used Oxacillin (1 microg), Cephalexin (10 Ofloxacin(5 Fusidic acid Penicillin Vancomycin (30 Erythromycin (15 Gentamicin Teicoplanin Amikacin microg) Clindamycin (2 microg). RESULTS: Our results indicate that out 190 positive S. aureus, 82 (43%) found to be MRSA. These strains also resistant many other antistaphylococcal antibiotics. CONCLUSION: A total isolated various samples. Pattern first line antibiotics is changing. crucial treatment these patients.

参考文章(12)
M. Aires de Sousa, I. Santos Sanches, M. L. Ferro, M. J. Vaz, Z. Saraiva, T. Tendeiro, J. Serra, H. de Lencastre, Intercontinental Spread of a Multidrug-Resistant Methicillin- Resistant Staphylococcus aureus Clone Journal of Clinical Microbiology. ,vol. 36, pp. 2590- 2596 ,(1998) , 10.1128/JCM.36.9.2590-2596.1998
Michael Whitby, Fusidic acid in the treatment of methicillin-resistant Staphylococcus aureus. International Journal of Antimicrobial Agents. ,vol. 12, ,(1999) , 10.1016/S0924-8579(98)00075-2
Adriaan Willem Sturm, R Van der Pol, AJ Smits, FM Van Hellemondt, SW Mouton, Bushra Jamil, AM Minai, GH Sampers, Over-the-counter availability of antimicrobial agents, self-medication and patterns of resistance in Karachi, Pakistan. Journal of Antimicrobial Chemotherapy. ,vol. 39, pp. 543- 547 ,(1997) , 10.1093/JAC/39.4.543
Derek F. J. Brown, David I. Edwards, Peter M. Hawkey, Donald Morrison, Geoffrey L. Ridgway, Kevin J. Towner, Michael W. D. Wren, Guidelines for the laboratory diagnosis and susceptibility testing of methicillin-resistant Staphylococcus aureus (MRSA) Journal of Antimicrobial Chemotherapy. ,vol. 56, pp. 1000- 1018 ,(2005) , 10.1093/JAC/DKI372
Adelisa L. Panlilio, David H. Culver, Robert P. Gaynes, Shailen Banerjee, Tonya S. Henderson, James S. Tolson, William J. Martone, , Methicillin-resistant Staphylococcus aureus in U.S. hospitals, 1975-1991. Infection Control and Hospital Epidemiology. ,vol. 13, pp. 582- 586 ,(1992) , 10.1086/646432
Theresa L. Smith, Michele L. Pearson, Kenneth R. Wilcox, Cosme Cruz, Michael V. Lancaster, Barbara Robinson-Dunn, Fred C. Tenover, Marcus J. Zervos, Jeffrey D. Band, Elizabeth White, William R. Jarvis, Emergence of Vancomycin Resistance in Staphylococcus aureus The New England Journal of Medicine. ,vol. 340, pp. 493- 501 ,(1999) , 10.1056/NEJM199902183400701
Howard S. Gold, Robert C. Moellering, Antimicrobial-drug resistance The New England Journal of Medicine. ,vol. 335, pp. 1445- 1453 ,(1996) , 10.1056/NEJM199611073351907