Comparison of silver sulfadiazine 1%, mupirocin 2%, and fusidic acid 2% for topical antibacterial effect in methicillin-resistant staphylococci-infected, full-skin thickness rat burn wounds.
作者： Cengiz Acikel , Oral Oncul , Ersin Ulkur , Ismail Bayram , Bahattin Celikoz
DOI: 10.1097/00004630-200301000-00008
关键词: Microbiology 、 Silver sulfadiazine 、 Antibacterial agent 、 Staphylococcus aureus 、 Eschar 、 Medicine 、 Mupirocin 、 Micrococcaceae 、 Meticillin 、 Fusidic acid
摘要: Silver sulfadiazine 1%, mupirocin 2%, and fusidic acid 2% were compared to assess the antibacterial effect of a once-daily application on experimental rat 15% full-skin thickness burn wounds seeded 24 hours earlier with 10 8 standard strain methicillin-resistant staphylococci. The quantitative counts organism in eschar subjacent muscle determined at postburn day 7, beside cultures blood lung biopsies. All tested topical agents equally effective against Staphylococcus aureus reducing local wound bacterial count preventing systemic infection.
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sci-hub.se 参考文章(27)
Gerald L. Mandell, R. Gordon Douglas, John E. Bennett, Principles and Practice of Infectious Diseases ,(1985)
Total Burn Care Journal of Intensive Care Medicine. ,vol. 12, pp. 110- 111 ,(1997) , 10.1016/B978-1-4160-3274-8.X5001-6
A.M. AL-HADDAD, E.E. UDO, S.C. SANYAL, E.M. MOKADAS, W.B. GRUBB, Persistence of a clone of methicillin-resistant Staphylococcus aureus in a burns unit. Journal of Medical Microbiology. ,vol. 50, pp. 558- 564 ,(2001) , 10.1099/0022-1317-50-6-558
H Rode, D Hanslo, P M de Wet, A J Millar, S Cywes, Efficacy of mupirocin in methicillin-resistant Staphylococcus aureus burn wound infection. Antimicrobial Agents and Chemotherapy. ,vol. 33, pp. 1358- 1361 ,(1989) , 10.1128/AAC.33.8.1358
Shanta M. Modak, Lester Sampath, C. L. Fox, Combined topical use of silver sulfadiazine and antibiotics as a possible solution to bacterial resistance in burn wounds. Journal of Burn Care & Rehabilitation. ,vol. 9, pp. 359- 363 ,(1988) , 10.1097/00004630-198807000-00009
HARREL L. WALKER, ARTHUR D. MASON, A standard animal burn. Journal of Trauma-injury Infection and Critical Care. ,vol. 8, pp. 1049- 1051 ,(1968) , 10.1097/00005373-196811000-00006
Michael Whitby, Fusidic acid in the treatment of methicillin-resistant Staphylococcus aureus. International Journal of Antimicrobial Agents. ,vol. 12, ,(1999) , 10.1016/S0924-8579(98)00075-2
Mita Prasanna, C Thomas, A profile of methicillin resistant Staphylococcus aureus infection in the burn center of the Sultanate of Oman Burns. ,vol. 24, pp. 631- 636 ,(1998) , 10.1016/S0305-4179(98)00108-9
Nicola Cook, Methicillin-resistant Staphylococcus aureus versus the burn patient Burns. ,vol. 24, pp. 91- 98 ,(1998) , 10.1016/S0305-4179(97)00114-9
M.J. Vizcaino-Alcaide, R. Herruzo-Cabrera, J. Rey-Calero, Efficacy of a broad-spectrum antibiotic (mupirocin) in an in vitro model of infected skin Burns. ,vol. 19, pp. 392- 395 ,(1993) , 10.1016/0305-4179(93)90059-H