Use of the Surgical Wound Infection Model To Determine the Efficacious Dosing Regimen of Retapamulin, a Novel Topical Antibiotic
作者： Stephen Rittenhouse , Christine Singley , Jennifer Hoover , Roni Page , David Payne
DOI: 10.1128/AAC.00183-06
关键词:
摘要: The effect of topically applied retapamulin ointment was evaluated using various dosing regimens in the Staphylococcus aureus and Streptococcus pyogenes wound infection model. Retapamulin (1%, wt/wt) efficacious twice-daily (b.i.d.) applications for 4 or 5 days. These data underpinned decision to evaluate 1% b.i.d. clinical trials.
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