Fusidic acid in vitro activity.

摘要: Fusidic acid is a narrow spectrum agent that acts to inhibit protein synthesis by inhibition of elongation factor G at the level ribosome. Because high binding susceptibility testing in vitro affected presence blood or serum. In addition, there modest inoculum effect vitro. A breakpoint 1 2 mg/l most widely used for defining resistance systemic treatment with fusidic acid. activity principally directed staphylococci, both Staphylococcus aureus and coagulate-negative species which are highly susceptible. It also active against Gram-positive anaerobic activity, shows Neisseria spp., Bordetella pertussis Moraxella catarrhalis. has no other aerobic Gram-negative species. Modest (MICs just above values) seen Streptococcus Enterococcus spp. as well bacteria. defined bacteriostatic. For staphylococci MBC values generally 8–32-fold MIC. Interaction studies antibiotics give varying results depending on methodology. However, interaction s-lactams indifferent, it rifampicin, while aminoglycosides macrolides appear be synergistic fluoroquinolones antagonistic. appears function neutrophils T-lymphocytes clinically achieved concentrations.