Pharmacokinetics of intravenous tramadol in dogs

摘要: The purpose of this study was to determine the pharmacokinetics tramadol and active metabolite mono-O-desmethyltramadol (M1) in 6 healthy male mixed breed dogs following intravenous injection at 3 different dose levels. Verification metabolism M1, which most analgesic activity agent is attributed to, a primary goal. Quantification parent compound M1 performed using gas chromatography. Pharmacodynamic evaluations were time patient sampling included assessment sedation, evaluation for depression heart respiratory rates. This confirmed that while these able produce administration tramadol, concentrations lower than previously reported research beagles. Adverse effects minimal, with mild dose-related sedation all nausea 1 dog. Analgesia not documented method used study. Tramadol may be useful canine patients, but additional studies population are required more accurately effective clinical use drug quantification wider patients.