Asymmetric iridium-catalyzed hydrogenation of 2-methylindole using phosphite ligands
作者： Sergey E. Lyubimov , Dmitry V. Ozolin , Vadim A. Davankov
DOI: 10.1016/J.TETLET.2014.04.113
关键词: Organic chemistry 、 Chemistry 、 Denticity 、 Asymmetric hydrogenation 、 Ligand 、 Polymer chemistry 、 2-Methylindole 、 Catalysis 、 Noyori asymmetric hydrogenation 、 Iridium 、 Biochemistry 、 Drug discovery
摘要: The iridium-catalyzed asymmetric hydrogenation of 2-methylindole using monodentate phosphites and amidophosphites as ligands was examined. use iodine the additive resulted in increased enantioselectivity conversion 2-methylindole. Full up to 80% ee were obtained with a catalyst based on phosphite ligand.
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