New 7‐substituted quinolone antibacterial agents. The synthesis of 1‐ethyl‐1,4‐dihydro‐4‐oxo‐7‐(2‐thiazolyl and 4‐thiazolyl)‐3‐quinolinecarboxylic acids
作者： Townley P. Culbertson , John M. Domagala , Phred Peterson , Shannon Bongers , Jeffrey B. Nichols
关键词: Chemistry 、 Moiety 、 Thiazole 、 Medicinal chemistry 、 Antibacterial activity 、 Organic chemistry 、 Amine gas treating 、 Biological activity 、 Bicyclic molecule 、 Thioamide 、 Antibacterial agent
摘要: A series of 1-ethyl-1,4-dihydro-4-oxo-7-(4-thiazolyl)-3-quinolinecarboxylic acids and 1-ethyl-1,4-dihydro-4-oxo-7-(2-thiazolyl)-3-quinolinecarboxylic were prepared. Also prepared was 10-[2-(aminomethyl)-4-thiazolyl]-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid. Analogs with basic amine substituents on the thiazole moiety found to have antibacterial activity.
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