Beneficial effects of ketogenic diets for cancer patients: a realist review with focus on evidence and confirmation
DOI: 10.1007/S12032-017-0991-5
关键词: Beneficial effects 、 Neoplasms therapy 、 Clinical psychology 、 MEDLINE 、 Human studies 、 Medicine 、 Ketogenic diet 、 Cancer 、 Quality of life
摘要: Ketogenic diets (KDs) have gained popularity among patients and researchers alike due to their putative anti-tumor mechanisms. However, the question remains which conclusions can be drawn from available human data thus far concerning safety efficacy of KDs for cancer patients. A realist review utilizing a matrix analytical approach was conducted according RAMESES publication standards. All studies were systematically analyzed supplemented with results animal studies. Evidence confirmation treated as separate concepts. In total, 29 24 included in analysis. The majority (72%) yielded evidence an effect KDs. Evidential support such effects humans weak limited individual cases, but probabilistic argument shows that strengthen belief hypothesis at least some individuals. pro-tumor lacking completely. Feasibility has been shown various contexts. probability achieving seems greater than causing serious side when offering Future controlled trials would provide stronger or against hypothesis.
springer.com
sci-hub.se 参考文章(124)
Rainer J. Klement, Restricting carbohydrates to fight head and neck cancer——is this realistic？ Cancer biology and medicine. ,vol. 11, pp. 145- 161 ,(2014) , 10.7497/J.ISSN.2095-3941.2014.03.001
Zaheed Husain, Yannu Huang, Pankaj Seth, Vikas P. Sukhatme, Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells Journal of Immunology. ,vol. 191, pp. 1486- 1495 ,(2013) , 10.4049/JIMMUNOL.1202702
Gabriele D Maurer, Daniel P Brucker, Oliver Bähr, Patrick N Harter, Elke Hattingen, Stefan Walenta, Wolfgang Mueller-Klieser, Joachim P Steinbach, Johannes Rieger, Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy. BMC Cancer. ,vol. 11, pp. 315- 315 ,(2011) , 10.1186/1471-2407-11-315
Iman M. Ahmad, Nukhet Aykin-Burns, Julia E. Sim, Susan A. Walsh, Ryuji Higashikubo, Garry R. Buettner, Sujatha Venkataraman, Michael A. Mackey, Shawn W. Flanagan, Larry W. Oberley, Douglas R. Spitz, Mitochondrial and H2O2Mediate Glucose Deprivation-induced Stress in Human Cancer Cells Journal of Biological Chemistry. ,vol. 280, pp. 4254- 4263 ,(2005) , 10.1074/JBC.M411662200
Antonio Paoli, Adriano Rubini, JS Volek, KA Grimaldi, None, Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets European Journal of Clinical Nutrition. ,vol. 67, pp. 789- 796 ,(2013) , 10.1038/EJCN.2013.116
Rainer J Klement, Ulrike Kämmerer, Is there a role for carbohydrate restriction in the treatment and prevention of cancer Nutrition & Metabolism. ,vol. 8, pp. 75- 75 ,(2011) , 10.1186/1743-7075-8-75
Melanie Schmidt, Nadja Pfetzer, Micheal Schwab, Ingrid Strauss, Ulrike Kämmerer, Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial Nutrition & Metabolism. ,vol. 8, pp. 54- 54 ,(2011) , 10.1186/1743-7075-8-54
David J. A. Jenkins, Julia M. W. Wong, Cyril W. C. Kendall, Amin Esfahani, Vivian W. Y. Ng, Tracy C. K. Leong, Dorothea A. Faulkner, Ed Vidgen, Kathryn A. Greaves, Gregory Paul, William Singer, The Effect of a Plant-Based Low-Carbohydrate (“Eco-Atkins”) Diet on Body Weight and Blood Lipid Concentrations in Hyperlipidemic Subjects JAMA Internal Medicine. ,vol. 169, pp. 1046- 1054 ,(2009) , 10.1001/ARCHINTERNMED.2009.115
Eugene J. Fine, C.J. Segal-Isaacson, Richard D. Feinman, Silvia Herszkopf, Maria C. Romano, Norica Tomuta, Amanda F. Bontempo, Abdissa Negassa, Joseph A. Sparano, Targeting insulin inhibition as a metabolic therapy in advanced cancer: A pilot safety and feasibility dietary trial in 10 patients Nutrition. ,vol. 28, pp. 1028- 1035 ,(2012) , 10.1016/J.NUT.2012.05.001
Phillip Stafford, Mohammed G Abdelwahab, Do Kim, Mark C Preul, Jong M Rho, Adrienne C Scheck, The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma. Nutrition & Metabolism. ,vol. 7, pp. 74- 74 ,(2010) , 10.1186/1743-7075-7-74