Antibodies to Glutamic Acid Decarboxylase Reveal Latent Autoimmune Diabetes Mellitus in Adults With a Non—Insulin-Dependent Onset of Disease

摘要: The classification of adults with diabetes mellitus can be invalidated by patients who initially present as NIDDM but later become frankly insulin dependent. In some these, the pathogenesis could similar to that in IDDM, namely autoimmune destruction pancreatic β-cells. We studied 102 >35 yr age at onset had been nonketotic and non-insulin-dependent for ≥6 mo. They were classified according glucagonstimulated C-peptide levels into an insulin-deficient group ( n = 33) a non-insulin-deficient 69). measured antibodies GAD, islet cell cytoplasm, thyroid antigens, gastric parietal cells both groups. Anti-GAD was significantly higher deficient group, 76% (25 33), than non-insulin 12% (8 69), this difference substantially greater shown ICAs. Thus, proportion NIDDM, slowly evolving insulitis revealed testing anti-GAD. This have important connotations not only early intervention, also correct diabetes.