DPY-26, a Link Between Dosage Compensation and Meiotic Chromosome Segregation in the Nematode
作者： J. D. Lieb , E. E. Capowski , P. Meneely , B. J. Meyer
DOI: 10.1126/SCIENCE.274.5293.1732
关键词: Premature chromosome condensation 、 Dosage compensation 、 Meiotic chromosome segregation 、 Dosage compensation complex 、 Gene dosage 、 Genetics 、 Biology 、 Meiosis 、 Chromosome segregation 、 X chromosome
摘要: The DPY-26 protein is required in the nematode Caenorhabditis elegans for X-chromosome dosage compensation as well proper meiotic chromosome segregation. was shown to mediate both processes through its association with chromosomes. In somatic cells, associates specifically hermaphrodite X chromosomes reduce their transcript levels. germ all role X-specific localization of requires two proteins (DPY-27 and DPY-30) that coordinately control sex determination (SDC-2 SDC-3).
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