Developmental genetics of Caenorhabditis elegans sex determination.
作者： Patricia E. Kuwabara
DOI: 10.1016/S0070-2153(08)60271-9
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摘要: The nematode Caenorhabditis elegans has two naturally occurring sexes: a self-fertile XX hermaphrodite that first produces sperm, then oocytes, and an XO male. primary determinant of sex is the X:A ratio, number X chromosomes to sets autosomes. ratio regulates not only determination, but also dosage compensation. In intervening years since identification most key regulatory genes respond have been genetically identified ordered into hierarchies. Advances made in identifying chromosome numerator elements ratio. This review highlights genetic, molecular, biochemical approaches led understanding how these interact control determination discusses differences between sexual cell fate soma germ line C. addresses role germ-line-specific regulation controlling sperm-oocyte decision line. Finally, strategies take advantage availability entire genome sequence, which expected be completed 1998, are discussed for hitherto unidentified may play fate.
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