The sex-determining gene doublesex in the fly Megaselia scalaris: conserved structure and sex-specific splicing.
作者： Sylvia Kuhn , Volker Sievert , Walther Traut
DOI: 10.1139/G00-078
关键词:
摘要: The well-known sex-determining cascade of Drosophila melanogaster serves as a paradigm for the pathway to sexual development in insects. But primary signal and subsequent step, Sex-lethal (Sxl), have been shown not be functionally conserved non-Drosophila flies. We isolated doublesex (dsx), which is downstream step cascade, from phorid fly Megaselia scalaris, distant relative D. melanogaster. Conserved properties, e.g., sex-specific splicing, structure female-specific 3' splice site, splicing enhancer region with binding motifs TRA2/RBP1/TRA complex that activates Drosophila, domains DNA-binding oligomerization putative DSX protein, indicate functional conservation dsx M. scalaris. Hence, appears among flies probably an even wider group insects, analysis published cDNA silkmoth ind...
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